Fig 2.

Kaplan-Meier curves for the (A) primary composite end point of arterial or venous thrombosis, serious hemorrhage, or death from vascular causes; (B) overall survival; (C) composite end point of rate of transformation to myelofibrosis (MF), acute myeloid leukemia (AML), or myelodysplastic syndrome (MDS); (D) transformation to polycythemia vera (PV); (E) composite end point of any major disease-related complication (arterial thrombosis, venous thromboembolism, major hemorrhage, transformation to AML, MDS, MF, or death from any of these causes). (F) Box plots showing summary scores for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 questionnaire, performed at baseline and annually for 5 years after study entry; there were no significant differences between the study arms at any time point. Box and whisker plot showing median and vertical whisker showing 2nd and 98th percentile. HC, hydroxycarbamide.