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. Author manuscript; available in PMC: 2019 Jan 4.
Published in final edited form as: Mod Pathol. 2018 Jul 4;31(12):1787–1800. doi: 10.1038/s41379-018-0103-x

Figure 5. Morphologic and immunophenotypic features of subependymal giant cell astrocytoma -like astrocytoma with alternative lengthening of telomeres.

Figure 5

A subset of cases with subependymal giant cell astrocytoma -like morphology (a, d, g) were alternative lenghtening of telomeres -positive, as assessed by ultrabright telomere-specific FISH signals (b, e, h). ATRX demonstrated an aberrant pattern of staining in a subset of cells (arrows, c) and a concurrent ATRX mutation in case 7. The remaining cases had intact ATRX immunoreactivity and were wild type for the ATRX gene (f, i). Telomeric foci colocalized with PML bodies (arrow) (h, inset). Case 7=a,b,c; Case 2=d,e,f; Case 6=g,h,i.