Alpha-actinin |
TAPYRNVNIQNFHLSWK[73] |
stimulates gelation of F-actin and decreases its proteolysis |
[42, 73–75] |
Gelsolin |
two or more distinct 10–20 amino acid sequences including QRLFQKRGG |
inhibits severing and capping of actin filaments to prevent disassembly |
[27–29, 48, 76, 77] |
ezrin |
within N-terminal (1–309) part, amino acids 12–115 and 233–310. |
targeting to membrane and activation of actin binding |
[78–82] |
Profilin |
Short sequence centered on Arg88 |
release profilin from G-actin would lead to rapid actin assembly |
[1, 2, 83] |
Cofilin |
WAPECAPLKSKM |
inhibits severing activity |
[21]. |
Formins |
basic domain of mDia |
promotes actin filament nucleation and elongation |
[31, 32, 84] |
Talin |
cationic site in FERM domain |
localization to the plasma membrane followed by its activation. |
[43, 85] |
Vinculin |
multiple polycationic sites that can bind different acidic lipids |
links actin to transmembrane adhesion complexes. |
[42] |
Filamin |
FTRWCNEHLKCVSKRIANLQTDL |
inhibits actin gelation activity |
[86, 87] |
WASP |
polybasic domain |
releases N-WASP from an auto-inhibited state to promote actin assembly by activating the nucleating Arp2/3 complex; |
[30] |