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. 2018 Jul 19;103(12):1969–1979. doi: 10.3324/haematol.2018.190652

Figure 5.

Figure 5.

Twist1 deletion in the bone marrow microenvironment promotes the progression of acute myeloid leukemia. (A) Experimental scheme of the MLL-AF9 acute myeloid leukemia model and leukemic stem cell (LSC, GFP+c-Kit+Gr-1−) transplantation. (B) Kaplan–Meier survival curve of chimeric control (Ctrl) and knockout (KO) recipient mice (n=5, three independent experiments, log-rank test). (C) Representative flow cytometry profiles of L-GMP (IL-7R−Lin−GFP+c-KithiCD34+CD16/32hi). (D) Frequency and absolute number of L-GMP in the bone marrow (BM) and spleen of Ctrl and KO recipients (n=5, three independent experiments. Column plots show the mean ± standard deviation. **P<0.01; ***P<0.001, Student t test). (E) Kaplan–Meier survival curve of mice transplanted with LSC from chimeric Ctrl and KO mice (n=6, two independent experiments, log-rank test).