Figure 1.

Expression of genes involved in a putative oncogenic pathway in primary chronic myeloid leukemia (CML) and healthy cells. The expression of MYC (A), miR-150 (B), MYB (C), miR-155 (D), PU.1 (E) and BCR-ABL1 (F) in CD34⁺ (left) and CD34⁻ (right) subpopulations from CML-chronic phase (CP) patients at diagnosis (n=28) or at the time of resistance to tyrosine kinase inhibitors (TKIs) (n=18) compared to that in the CD34⁺ or CD34⁻ subpopulations of healthy donors (n=10). Gene expression in each specific sample is indicated by dots; the boxes represent box-and-whisker plots. Red: bone marrow (BM) CML-CP samples; black: healthy peripheral blood mononuclear cells (PBMC); blue lines: median expression values. Significant differences (P-values) in the gene expression between CML and healthy CD34⁺ and CD34⁻ subpopulations are illustrated in the tables below each box-and-whisker plot. Unpaired two-tailed Student t-test was used to determine P-values.