Figure 6.

Comparison of the oncogenic pathway expression profiles in imatinib-sensitive (naive) K562, KCL-22 and imatinib-resistant K562R, KCL-22R chronic myeloid leukemia (CML) cell lines. BCR-ABL1, MYB, MYC, PU.1, miR-150 and miR-155 transcript levels in (A) KCL-22 and KCL-22R and in (B) K562 and K562R. Gene expression data for resistant cells represent the fold change (FC; 2^−ΔΔCt) in relation to corresponding gene expression for naive cells normalized to 1. Unpaired two-tailed Student t-test was used to determine P-values. ^*P<0.05, ^** P<0.01, and ^***P<0.001. Error bars represent standard deviations.