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. 2018 Nov 27;9(6):1035–1056. doi: 10.1007/s13244-018-0666-6

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Histopathological features of fibrous dysplasia (FD). FD lesions are composed of fibrous tissue interspersed between bone trabeculae. The amount of bone within lesions is quite variable. Trabeculae are dysplastic, non-stress oriented, and appear disorganised. Haematoxylin-eosin stained sections in low (a) and high power (b) show irregular, discontinuous trabeculae (b) within a fibrous stroma (ft), demonstrating the typical “alphabet soup” pattern. Goldner’s trichrome stained sections in low (c) and high power (d) reveal osteomalacic changes including excess osteoid (asterisks) and severe undermineralisation of the dysplastic bone (reprinted from Boyce [34])