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. 2018 Nov 30;8:17492. doi: 10.1038/s41598-018-35681-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Number of differentially expressed proteins in E10.5 and E11.5 embryos’ heads, identified by LC-MS/MS, following antenatal E9.5 ATRA (100 mg/Kg) in vivo treatment. Two successive ANOVA test were performed (one on peptides and one on proteins). The quantitative data were only considered at the level of proteins if a minimum of 2 peptides by proteins were quantified. In total, 253 proteins were found dysregulated with a fold change superior or equal at 1.5 at E10.5 and E11.5. Among them, 16 proteins were found dysregulated at both exposure times (upper panel). Among these 253 proteins, 130 have been up-regulated (red) and 117 have been down-regulated (green) and 6 presented an opposite dysregulation between both exposure time (bottom panel).