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. 2018 Nov 30;8:17492. doi: 10.1038/s41598-018-35681-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Up and/or down-regulated proteins by ATRA treatment linked with Eftud2 and Gnai3 respectively following STRING software analysis. STRING analysis with mus musculus as reference is performed on all dysregulated proteins identified by our proteomics analysis at E10.5 and E11.5 following ATRA treatment at E9.5. Of all the deregulated proteins, those directly linked with Eftud2 (three right panels) and Gnai3 (fourth panel) are reported in this table. Dark-gray (+) and light-gray (−) represent respectively an increase and a decrease of protein expression by LC-MS/MS analysis. Hsp90ab1 and Hsp90ab1 underlined were linked to both Eftud2 and Gnai3 following STRING analysis