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. 2018 Nov 30;8:17480. doi: 10.1038/s41598-018-35772-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Purification microdevice. (a) Overview of the prototype microdevice for miRNA purification. (b) Cross-section of the microdevice. (c–f) Protocol of the purification microdevice. (c) First, sample is applied to the column module. (d) Then, the sample is absorbed into the FTA elute card on the reactor module. Excessive sample is absorbed by the filter paper. After drying the FTA elute card, (e) the column module is ejected, and (f) MilliQ water and mineral oil are applied to the reactor module. By heating the device via the ITO heater at 98 °C for 30 min, the purified miRNA was released from the FTA elute card and total miRNA is purified. (g) Expression level of miR-224 purified on the purification microdevice. The PC was generated by purification using the FTA elute card according to the manufacturer’s instructions. The graph shows the relative expression level of miR-224. The error bars represent standard deviation.