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. 2018 Nov 30;8:17468. doi: 10.1038/s41598-018-35868-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association between MYCN and FOXM1 in the ESC mRNA signature score. (A) ESC mRNA signature score upon lentiviral knock-down of MYCN in IMR-32 neuroblastoma cells, (B) upon pharmacological inhibition of MYCN with JQ1 in SKNBE(2)-C and Kelly neuroblastoma cells, (C) after inhibition of MYCN with JQ1 and OTX015 in IMR-5 neuroblastoma cells (p-values from Mann-Whitney tests), and (D) during tumor development in Th-MYCN mouse model. (E) Heatmap of expression of the top 50 correlated genes of the ESC mRNA signature in the Th-MYCN mouse model. (F,G) ESC mRNA signature score in neuroblastoma patient samples with and without MYCN amplification in a global cohort (F) and in stage 4 neuroblastoma patient samples (G). (H) ChIP-seq profiles of H3K27 and MYCN transcription factor binding at the FOXM1 promotor in both MYCN amplified (NGP, BE2C, KELLY) and MYCN non amplified (CLB-GA, qval = 6.3 × 10⁻⁵) cell lines as well as the SHEP21N cell line with induced MYCN expression.