Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 30;8:263. doi: 10.1038/s41398-018-0310-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — A The 10 mg/kg ketamine infusion significantly delayed cued fear extinction (day 2). Fear retrieval and extinction were tested over 12 auditory tone trials (each block represents an average of two trials) in novel Context B on days 2 and 3. B The 10 mg/kg dose significantly increased total freezing based on the AUC calculation. C The second fear extinction test on day 3 indicates a rapid extinction and there was no significant difference between the saline and the ketamine groups at the end of the testing. D There was no significant difference between the saline and ketamine groups on total freezing on day 3. E The ketamine group exhibited increased contextual fear recall as compared with the saline group on day 4. F However, cued fear recall was not significantly different between the groups. Contextual fear recall is expressed as % freezing of the initial 180-s in Context A and cued fear recall is expressed as % freezing of 300-s after a single 20-s auditory tone presentation. Data are shown as mean ± SEM (*p < 0.05, **p < 0.01 vs. saline controls)