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. 2018 Nov 30;8:263. doi: 10.1038/s41398-018-0310-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Fear memory retrieval and extinction was not significantly different between the ketamine and saline groups when the animals were tested first time (day 2). Each block represents an average of two tone trials in the Context B. B The area under the curve (AUC) was not different between the ketamine and saline groups (day 2). C The ketamine group showed a facilitated fear extinction during the second cue test on day 3. D The AUC was significantly lower in the ketamine group as compared to the saline group on day 3. E The fear recall to the context A (fear conditioning chamber) was not different between the ketamine and saline groups on day 4. F The fear recall to the auditory tone (CS) was significantly reduced in the ketamine group as compared to the saline group on day 4. Contextual fear recall is expressed as % freezing during the initial 180 s in Context A and cued fear recall is expressed as % freezing during the 300 s after the single 20-s auditory tone presentation (day 4). Data are shown as mean ± SEM (*p < 0.05 vs. saline controls)