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. 2018 Nov 30;8:17514. doi: 10.1038/s41598-018-35746-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of mXYSRa as the responsible sequence of mXYSR. (A) A result of MultiPipMaker analysis. Mouse, opossum, and chicken sequences homology at 50% or more to human XYSR (shown horizontally) are plotted by MultiPipMaker. Positions in XYSR are shown at the bottom. Species and homology levels are indicated at the left and right, respectively. (B,C) Results of genome editing of the mXYSRa and mXYSRb. Positions of sgRNAs and PCR primers are shown with arrowheads and arrows, respectively, on genome sequences (black lines). Black boxes indicated mXYSRa/mXYSRb. Sequences of deleted alleles are shown with electropherograms at the bottom. Positions of deleted sequences are indicated with dotted lines. The deleted lengths are shown between dotted lines. The inserted sequence is indicated with a blue box. Electropherogram of mXYSRa is shown after the original image was reverse complemented using FinchTV software. (D) Phenotypes of mXYSRa/mXYSRb homozygous deleted mice. Extra genitalia are shown with genotype. Testis and ovary are indicated with arrowheads labeled T and O, respectively. Scale bar: 1 mm.