Fig. 1.

Chromatin remodeling (alterations in the differentially accessible regions) in the process of NK cell transitioning from naïve to long-lived stages. A majority of these epigenetic changes occurred by day14 after infection and minimal changes continued to occur as the differentiating NK cells transitioned between days 14 and 35. While many of these changing regions returned to the naïve levels, a sizable portion of these regions (at least~30%) remained at a substantially altered state of accessibility. The greatest global changes occurred during the first week of viral infection and relatively little epigenetic modulation occurred between days 14 and 35