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The effect of Colchicine derivatives (A and B) on ROS formation in both healthy and ALL mitochondria. Freshly isolated purified mitochondria were obtained from both healthy and ALL donors incubated with of colchicine derivatives (A and B) for 1 h. Columns represent mean of DCF fluorescence intensity in ALL and healthy B-lymphocytes treated with colchicine derivatives for 0–60 min. Values (mean ± S.D.) are from three independent experiments (n = 6) ****p < 0.0001
