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. 2018 Autumn;17(4):1537–1549.

Figure 1.

Figure 1

AptNCL-let-7d conjugates design and formation. (A) Schematic illustration of aptNCL-let-7d conjugate using covalent SM (PEG)2 crosslinker (conjugate-1). (B) Schematic illustration of annealed aptNCL-let-7d conjugate using non-covalent sticky-end hybridization (conjugate-2). To confirm the formation of the conjugates, (C) let-7d, aptNCL, the conjugate-1 (D) let-7d-stick, aptNCL-stick and the conjugate-2 were assessed on 15% non-denaturing polyacrylamide gel and stained by SYBR Green DNA safe stain.