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(A) Cytotoxicity study of RGD-MEKI conjugates 9b, 9f–h, compared with the parent drug (PD0325901) and MEKI—8b on different tumor cell lines (melanoma-A375, glioblastoma-U87, NSCLC-A549) at 10 µM concentration by the SRB method. (B) IC50 value of 8b, 9b, 9f and 9g in A375 cells. The effect of cRGD peptide cargo on conjugates was analyzed by student’s t-test, and (*) indicates p value < 0.05, (**) indicates p value < 0.01.
