Table 3.

HCCP-mediated formation of quinazoline ethers from quinazolin-4(3H)-ones ^a.

Entry	Quinazolin-4(3H)-one	ArOH or RONa	Product		Yield (%) b
1	1a			18	75
2	1a			19	52
3	1a			20	73
4	1a			21	51
5	1b			22	53 c
6	1f			23	70
7	1g			24	70
8	1a	CH3CH2ONa		25	54
9	1b	CH3CH2ONa		26	33 c
10	1d	CH3CH2ONa		27	67
11	1g	CH3CH2ONa		28	64
12	1a	CH3CH2CH2ONa		29	48

^a Reagents and Conditions: 1 (0.5 mmol), HCCP (1.1 equiv.), DIPEA (5.0 equiv.), MeCN (5 mL), rt, activation time (1 h), then phenols (5.0 equiv.), 45 °C, 23 h; or R²ONa (5.0 equiv.), 45 °C, 3 h; ^b Isolated yield; ^c Activation time (20 h).