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. 2013 Aug 16;18(8):9833–9849. doi: 10.3390/molecules18089833

Scheme 1.

Scheme 1

Huisgen 1,3-dipolar cycloaddition—copper(I) catalyzed reaction of terminal alkynes with azides (CuAAC) and copper-free strain-promoted alkyne-azide cycloaddition (SPAAC).