Table 5.
1H-NMR data of compounds 1–7 in CDCl3 (δ in ppm and J in Hz).
| No. | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
| N1-H | 4.96 (s) | 4.98 (s) | 5.00 (s) | 5.04 (s) | 4.43 (s) | - | - |
| 3 | - | - | - | 3.96 (m) | 3.36 (m) | 4.73 (dd, 14.0,4.0) | 4.48 (dd, 14.0,4.0) |
| 5α | - | - | - | - | - | 2.18 (m) | - |
| 5β | 4.88 (dd, 4.2,3.6) | 4.86 (d, 5.2) | 4.92 (dd, 4.0,3.6) | 5.28 (dd, 4.0,3.8) | 4.92 (dd, 7.2,5.6) | 2.32 (m) | 3.84 (dd, 4.0,3.8) |
| 6α | 2.25 (dd, 13.6,4.2) | 2.26 (d, 13.8) | 2.29 (d, 14.0) | 2.75 (dd, 14.0,4.0) | 2.76 (dd, 14.4,5.6) | 2.06 (m) | 2.20 (dd, 14.0,4.0) |
| 6β | 3.41 (dd, 13.6,3.6) | 3.48 (dd, 13.8,5.2) | 3.52 (dd, 14.0,5.2) | 3.08 (dd, 14.0,3.8) | 3.10 (dd, 14.4,7.2) | 2.33 (m) | 3.75 (dd, 14.0,3.8) |
| 9 | 7.31 (dd, 7.8,1.8) | 7.72 (dd, 8.2,2.0) | 7.76 (dd, 7.8,2.0) | 7.12 (dd, 8.2,1.8) | 7.14 (dd, 8.0,2.0) | 7.76 (dd, 7.8,2.0) | 7.79 (dd, 8.0,2.0) |
| 10 | 6.84 (dt, 7.8,1.8) | 6.70 (dt, 8.2,2.0) | 6.82 (dt, 7.8,2.0) | 6.78 (dt, 8.2,1.8) | 6.77 (dt, 8.0,2.0) | 6.92 (dt, 7.8,2.0) | 7.39 (dt, 8.0,2.0) |
| 11 | 7.08 (dt, 7.8,1.8) | 6.98 (dt, 8.2,2.0) | 7.14 (dt, 7.8,2.0) | 7.06 (dt, 8.2,1.8) | 7.10 (dt, 8.0,2.0) | 7.24 (dt, 7.8,2.0) | 7.14 (dt, 8.0,2.0) |
| 12 | 6.68 (dd, 7.8,1.8) | 6.66 (dd, 8.2,2.0) | 6.78 (dd, 7.8,2.0) | 6.56 (dd, 8.2,1.8) | 6.66 (dd, 8.0,2.0) | 6.79 (dd, 7.8,2.0) | 7.32 (dd, 8.0,2.0) |
| 14α | 2.26 (dd, 14.0,3.8) | 2.30 (dd, 14.0,3.8) | 2.33 (dd, 13.8,3.8) | 2.23 (m) | 2.25 (m) | 2.27 (m) | 2.88 (m) |
| 14β | 2.18 (dd, 14.0,4.0) | 2.27 (dd, 14.0,4.0) | 2.29 (dd, 13.8,4.0) | 1.91 (m) | 1.93 (m) | 2.24 (m) | 1.96 (m) |
| 15 | 3.63 (dd, 4.0,3.8) | 3.69 (dd, 4.0,3.8) | 3.72 (dd, 4.0,3.8) | 2.95 (dd, 4.0,3.8) | 2.97 (dd, 4.0,3.8) | 3.62 (dd, 4.0,3.8) | 3.66 (dd, 4.0,3.8) |
| 16 | - | - | - | 2.92 (d, 4.8) | 2.59 (d, 4.2) | - | - |
| 17a | 8.52 (s) | 3.32 (d, 13.8) | 3.87 (d, 13.6) | - | - | 8.55 (s) | 3.68 (d, 13.2) |
| 17b | - | 3.46 (d, 13.8) | 4.01 (d, 13.6) | - | - | - | 3.91 (d, 13.2) |
| 18 | 1.51 (d, 7.0) | 1.55 (d, 7.2) | 1.58 (d, 7.0) | 1.40 (d, 7.0) | 1.41 (d, 6.8) | 1.83 (d, 7.2) | 1.55(d, 7.0) |
| 19 | 5.47 (q, 7.0) | 5.48 (q, 7.2) | 5.50 (q, 7.0) | 2.93 (q, 7.0) | 2.95 (q, 6.8) | 5.86 (d, 7.2) | 5.54(d, 7.0) |
| 21α | 3.85 (d, 13.8) | 3.87 (d, 14.2) | 3.89 (d, 13.8) | 3.36 (d, 14.0) | 3.39 (d, 14.0) | 3.88 (d, 13.8) | 4.07 (d, 13.6) |
| 21β | 3.31 (d, 13.8) | 3.33 (d, 14.2) | 3.35 (d, 13.8) | 3.08 (d, 14.0) | 3.11 (d, 14.0) | 3.35 (d, 13.8) | 3.08 (d, 13.6) |
| CO2CH3 | 3.69 (s) | 3.78 (s) | 3.82 (s) | 3.70 (s) | 3.67 (s) | 3.80 (s) | 3.71 (s) |
| N1-CH3 | - | - | - | - | 2.03 (s) | - | |
| OCH3 | 3.50 (s) | 3.52 (s) | 3.53 (s) | 3.10 (s) | 3.41 (s) | - | 3.25 (s) |
| COCH3 | - | - | 1.53 (s) | - | - | - |