Table 2.
Summary of responses of filamentous fungi to KA-mediated chemosensitization with H2O2 or complex III inhibitors (agar plate bioassay) a.
| Strains | H2O2 | Kre-Me | PCS | AntA |
|---|---|---|---|---|
| Human pathogens | ||||
| A. fumigatus MYA-3626 | ++ | + | ++ | + |
| A. fumigatus AF293 | + b | + | ++ | + |
| A. fumigatus AF10 | ++ | + | ++ | + |
| A. fumigatus 94-46 | + | + | ++ | + |
| A. fumigatus 92-245 | + | + | ++ | + |
| A. terreus UAB673 | ++ b | + | ++ | - |
| A. terreus UAB680 | + b | + | ++ | - |
| A. terreus UAB698 | ++ b | - | - | - |
| Acremonium sp. 95-103 | ++ | ++ | n/t c | ++ |
| Scedosporium sp. 09-246 | + | ++ | n/t c | ++ |
| Penicillium strains | ||||
| P. expansum 974 | ++ | - | - | - |
| P. expansum W1 | + | - | - | - |
| P. expansum FR2 | + | - | ++ | - |
| P. expansum W2 | ++ | - | - | - |
| P. expansum FR3 | ++ | - | + | - |
| P. chrysogenum 824 | ++ | - | - | - |
| P. griseofulvum 2159 | ++ | - | - | - |
| P. griseofulvum 2300 | - | - | - | - |
| P. digitatum 786 | ++ | n/t d | n/t c | + |
| P. italicum 983 | - | + | ++ | - |
| P. glabrum 766 | - | + | + | + |
| Other Aspergillus strains | ||||
| A. flavus 4212 | - | - | - | - |
| A. parasiticus 2999 | - | - | - | - |
| A. oryzae A815 | - | - | - | - |
| A. niger 326 | - | - | - | - |
| A. ochraceous 5175 | - | - | - | - |
| A. nidulans A4 | - | + | + | - |
a +, Enhancement of antifungal activity after co-application (reduced radial growth of fungi); ++, Enhancement of antifungal activity after co-application (no germination of fungi); -, No enhancement of antifungal activity after co-application. b [25]. c n/t, Not tested due to no growth of fungi w/ PCS (25 μM) alone (i.e., hypersensitivity to PCS alone). d n/t, Not tested due to no growth of fungi w/ Kre-Me (25 μM) alone (i.e., hypersensitivity to Kre-Me alone).