. 2013 Jan 25;18(2):1564–1581. doi: 10.3390/molecules18021564

Table 4.

Antifungal chemosensitization of KA (mM) to Kre-Me (μg/mL) tested against Acremonium, Scedosporium or P. digitatum strains: summary of CLSI-based microdilution bioassays ^a.

Strains	Compounds	MIC alone	MIC combined	FICI
Acremonium sp. 95-103	KA	64	8	0.2
Acremonium sp. 95-103	Kre-Me	16	1	0.2
Scedosporium sp. 09-246	KA	64	8	0.2
Scedosporium sp. 09-246	Kre-Me	>16 ^b	1	0.2
P. digitatum 786	KA	>64 ^c	8	0.1
P. digitatum 786	Kre-Me	8	0.5	0.1
Mean	KA	85.3	8	0.1
Mean	Kre-Me	18.7	0.8	0.1
t-test ^d	KA	-	p < 0.05	-
t-test ^d	Kre-Me	-	p < 0.1	-
Strains	Compounds	MFC alone	MFC combined	FFCI
Acremonium sp. 95-103	KA	>64	64	0.6
Acremonium sp. 95-103	Kre-Me	>16	2	0.6
Scedosporium sp. 09-246 & P. digitatum 786	KA	>64	>64	2
Scedosporium sp. 09-246 & P. digitatum 786	Kre-Me	>16	>16	2
Mean	KA	128	106.7	1.5
Mean	Kre-Me	32	22	1.5
t-test ^d	KA	-	p < 0.5	-
t-test ^d	Kre-Me	-	p < 0.5	-

^a MIC: Minimum inhibitory concentration, MFC: Minimum fungicidal concentration, FICI: Fractional Inhibitory Concentration Indices, FFCI: Fractional Fungicidal Concentration Indices. Synergistic FICIs were in bold. ^b Kre-Me was tested up to 16 μg/mL. For calculation purpose, 32 μg/mL (doubling of 16 μg/mL) was used. ^c KA was tested up to 64 mM. For calculation purpose, 128 mM (doubling of 64 mM) was used. ^d Student’s t-test for paired data (combined, i.e., chemosensitization) was vs. mean MIC or MFC of each compound (alone, i.e., no chemosensitization) determined in three strains (Calculation was based on [39]).