Table 2.
Effect of extracts on tissue δ-ALA-D and AChE activity in rat homogenates.
| Treatment | δ-ALA-D | AChE | ||
|---|---|---|---|---|
| Liver | Brain | Kidney | ||
| Control (PBS) | 4.33 ± 0.48 | 1.23 ± 0.18 | 1.49 ± 0.43 | 2.78 ± 0.14 |
| Lead acetate 10 µM | 2.92 ± 0.23 | 0.95 ± 0.02 | 0.99 ± 0.43 | - |
| Paraoxon 1 µM | - | - | - | 1.26 ± 0.07 *** |
| Syzygium jambos 100 µg/ mL | 4.85 ± 0.71 | 1.10 ± 0.06 | 1.89 ± 0.49 | 2.65 ± 0.14 |
| Syzygium jambos 250 µg/mL | 4.09 ± 0.46 | 1.38 ± 0.28 | 1.97 ± 0.53 | 2.75 ± 0.14 |
| Solanum guaraniticum 500 µg/mL | 4.24 ± 0.52 | 0.91 ± 0.11 | 1.66 ± 0.32 | 2.73 ± 0.14 |
| Solanum guaraniticum 1000 µg/mL | 4.31 ± 0.72 | 0.66 ± 0.14 * | 1.35 ± 0.18 | 2.79 ± 0.14 |
Data are reported as mean ± SEM (n = 6) and assessed by one way ANOVA followed by Duncan Multiple Comparison post hoc test. δ-aminolevulinate dehydratase activity (δ-ALA-D) results are presented as nmol porphobilinogen (PBG)/mg protein/h. Acetylcholinesterase actitivty (AChE) results are presented as µmol AcSCh/h/mg of protein. (*) and (***) denotes p < 0.05 and p < 0.0001 as compared to the respective control samples.