Table 1.
In vitro growth inhibitory concentrations that reduce cell growth by 50% (IC50; µM) for compounds 1–8 (Figure 1) following culturing of the cancer cell lines with the compound of interest for 72 h (MTT colorimetric assay).
| Compounds | Carcinoma | Glioma | Melanoma | Mean ± SEM | |||
|---|---|---|---|---|---|---|---|
| MCF-7 (breast) | A549 (NSCLC) | Hs683 | U373 | B16F10 * | SKMEL28 | ||
| (oligodendroglioma) | (astroglioma) | ||||||
| 1 | 4 | 3 | 3 | 3 | 4 | 4 | 4.0 ± 0.2 |
| 2 | 8 | 7 | 4 | 7 | 5 | 7 | 6.0 ± 0.6 |
| 3 | 7 | 8 | 4 | 11 | 6 | 7 | 7.0 ± 0.9 |
| 4 | >100 | >100 | >100 | >100 | 75 | >100 | >96 |
| 5 | 94 | >100 | >100 | >100 | 86 | >100 | >97 |
| 6 | >100 | >100 | >100 | >100 | 45 | >100 | >91 |
| 7 | >100 | >100 | >100 | >100 | 63 | >100 | >94 |
| 8 | 68 | 68 | 70 | 73 | 58 | 76 | 69 ± 3 |
* All the cell lines are of human origin except the B16F10 melanoma, which is of murine origin. NSCLC means non-small-cell lung cancer.