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Media pH (A), and corresponding 7 mM lactate generation and 5 mM glucose consumption after 24 h of incubation at 37 °C with and without serum (B). RITC-chitosan added to lactate-acidified media pH 6.5 remained 30% to 50% soluble compared to RITC-chitosan fully soluble in dilute HCl pH 5.6 (C).
