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. 2012 Dec 20;18(1):14–26. doi: 10.3390/molecules18010014

Table 1.

Optimization of the reaction conditions.

graphic file with name molecules-18-00014-i001.jpg
Entry [Rh] Solvent Base Yield (%) a ee (%) b
1 [Rh(coe)2Cl]2 dioxane KOH 96 78
2 [Rh(coe)2Cl]2 DME KOH 99 81
3 [Rh(coe)2Cl]2 DME K3PO4 59 73
4 [Rh(coe)2Cl]2 DME K2CO3 94 87
5 [Rh(coe)2Cl]2 DME NEt3 trace -
6 [Rh(nbd)2]BF4 DME K2CO3 57 87
7 [Rh(nbd)2]BF4 DME NEt3 99 92

a Isolated yield; b Determined by HPLC.