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Concentration-response curve of 8 (10−12–10−3 M) in cranial mesenteric artery rings isolated from rats with functional endothelium (•) and without functional endothelium (■) pre-contracted with PHE (1 μM). Values are expressed as mean ± standard error of mean (SEM), * p < 0.05 compared to the ring with functional endothelium.
