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Effects of GRZ on TNF-α and IL-1β mRNA in the brain tissue. GRZ significantly attenuated the up-regulation of brain TNF-α mRNA at all doses of 10, 30 and 50 mg/kg (A) IL-1β mRNA was attenuated at 30 and 50 mg/kg of GRZ; and (B) Data are represented by mean ± SEM (n = 6 in each group; * p < 0.05 compared to the LPS group).
