Scheme 1.
Synthesis of C-7-modified apigenin derivatives.
Reagents and conditions: (i) BrCH2CH2Br or BrCH2CH2CH2Br, K2CO3, DMF, 120 °C, 2 h; (ii) R-amines, DMF, 80 °C, 2 h to 4 h.
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