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. 2013 Mar 6;18(3):3018–3027. doi: 10.3390/molecules18033018

Table 1.

Biological activities of the compounds isolated from the Annonaceae and Monimiaceae plant families.

graphic file with name molecules-18-03018-i001.jpg
Compounds R0 R1 R2 R3 R4 R5 R6 R7 DYRK1A (IC50 in μM) a CDK1/Cyclin B (IC50 in μM) a
Aristolactams
aristolactam AII (1) H OH OCH3 H H H H H >30 >30
aristolactam BII (2) H OCH3 OCH3 H H H H H >30 >30
velutinam (3) H OCH3 OCH3 H H H OH H 0.6 1.5
aristolactam AIIIA (4) H OH OCH3 H OH H H H 0.08 0.2
N-Methylaporphines
(+)-corydine (6) H OCH3 OH OCH3 OCH3 H H CH3 >30 >30
(−)-roemerine (7) H O-CH2-O H H H H CH3 15.0 >30
(+)-bulbocapnine (9) H O-CH2-O OH OCH3 H H CH3 >30 >30
(+)-N-methyllindcarpine (10) H OH OCH3 OH OCH3 H H CH3 >30 >30
(+)-boldine (16) H OH OCH3 H OCH3 OH H CH3 >30 >30
Aporphines
(+)-actinodaphnine (11) H O-CH2-O H OCH3 OH H H >30 >30
(+)-11-methoxynorneolistine (12) H O-CH2-O OCH3 O-CH2-O H H 2.5 >30
(−)-O-methylisopiline (14) OCH3 OCH3 OCH3 H H H H H >30 >30
(+)-N-nornuciferine (15) H OCH3 OCH3 H H H H H 4.2 >30
Oxo-aporphines
liriodenine (8) H O-CH2-O H H H H - 3.1 >30
lysicamine (13) H OCH3 OCH3 H H H H - 2.4 >30
Other
(−)-medioresinol (5) 0.1 1.3
6-bromoindirubin-3'-monoxime b 0.52 0.32

a IC50 are mean values from triplicates (the variation is a maximum of 20%); b positive control; IC50 = 3 µg/mL on CDK1-CyclinB for G. dumontetii EtOAc extract, and IC50 = 3.6 and 1.0 μg/mL on DYRK1A for O. asbeckii EtOAc extract and S. pachyantha total alkaloid extract, respectively.