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. 2013 Jan 24;18(2):1383–1393. doi: 10.3390/molecules18021383

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© 2013 by the authors.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Muscle-specific Mn-SOD-deficient mice. (A) Cre recombinase is expressed under the control of a skeletal muscle-specific human skeletal actin (HSA) promoter. Cre recombinase recombines the loxP sites selectively to generate muscle-specific Mn-SOD-deficient mice; (B) Sections of gastrocnemius (Gastro) and tibialis anterior (TA) muscles from control mice (left panels) and muscle-Sod2^−/− mice (right panels). Examples of HE staining (top panels) and enzymatic staining for succinate dehydrogenase (SDH, middle panels) and cytochrome c oxidase activity (COX, bottom panels) are shown.