Table 2.
Inhibitory effects of selected sulfonamide chalcones on the cholinesterasesAChE and BChE.
| Compound | IC50a (μM) | Ki (μM)b | IC50a (μM) | Ki (μM)b |
|---|---|---|---|---|
| erythrocytes AChE | equine serum BChE | |||
| 4a | 56.1 | 40.4 | 47.4 | 25.3 |
| 4c | 83.3 | 80.3 | 75.0 | 72.2 |
| 4f | 95.8 | 61.5 | 34.3 | 19.0 |
| 5a | 75.9 | 55.8 | 19.5 | 9.8 |
| 5b | 75.4 | 57.2 | 79.0 | 63.5 |
| 5c | 57.4 | 47.6 | 24.7 | 26.6 |
| Eserin | 0.15 | NT c | 3.7 | NT |
a All compounds were examined in a set of experiments repeated three times; Error is standard deviation. IC50 values of compounds represent the concentration that caused 50% enzyme activity loss; b Values of inhibition constant; c NT is not tested.