Table 5.
Reaction conditions and yields of selected 18F-containing building blocks.
Building block | RCY
[%] |
RCP
[%] |
t
[min] |
AS
[GBq/µmol] |
Synthesis procedure | Literature |
---|---|---|---|---|---|---|
[18F]SFB | 25–38 | >95 | 70 | n.d. | automatically | [163] |
[18F]FBAM | 29 | 94–98 | 40 | 13–17 | automatically | [164] |
[18F]AFP [18F]47 | 25–50 | >97 | 40 | 3–6 | automatically | [78] |
[18F]BFP [18F]46 | 25–50 | >98 | 40 | 5–9 | automatically | [78] |
[18F]Fluorobutyne [18F]2a | 36 | >98 | 40 | n.d. | manually | [48] |
[18F]Fluoropentyne [18F]2b | 51 | >99 | 40 | n.d. | automatically | [50] |
[18F]FSi-based azide [18F]13 | 54 | >95 | 20 | n.d. | manually | [51] |
[18F]PEG3-alkyne [18F]23 | 57 | >99 | 40 | n.d. | automatic | [54] |
[18F]PEG3-azide [18F]27 | 62 | >99 | 40 | n.d. | manually | [55,56] |
[18F]FEA [18F]33 | 55 | >99 | 40 | n.d. | automatically | e.g., [57,58] |
[18F]FDG-β-Az [18F]78 | 71 | n.d. | 30 | n.d. | manually | [100] |
[18F]F-SA [18F]51 | 32 | >95 | 80 | 120–570 | automatically | [81,82,83] |
[18F]ArBF3- [18F]72 | 50 | 70 | 555 | manually | [95,96,97] | |
[18F]Fluoroethynylpyridine [18F]59 | 28 | >98 | 35 | n.d. | manually | [87] |
[18F]FB-DBCO [18F]82 | 85 (from SFB) | 95 | 60 (from SFB) | n.d. | manually | [105] |
[18F]ADIBO [18F]47 | 73–95 | 95 | 55 | 3.8 | manually | [111] |
[18F]FHP [18F]120 | 65 | n.d. | 10 | n.d. | manually | [135] |
[18F]TCO [18F]139 | 46 | >94 | 102 | n.d. | automatically | [157] |