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. 2013 May 16;18(5):5706–5722. doi: 10.3390/molecules18055706

Figure 4.

Figure 4

The conformational changes of the flap in BACE1. The superimposition of the X-ray crystal structures of BACE1 represented by pdb code 1FKN (cyan), 1W50 (green), 4IVT (yellow), and 4IVS (brown). The pdb code 4IVT and 4IVS represent the crystal structures of BACE1 complexed with the compounds 19 and 25, respectively.