Scheme 1.
The synthesis of compound 5.
Reagents and conditions: (a) K2CO3, acetone, reflux 5 h; (b) NaOH, THF/EtOH/H2O=2/2/1, reflux, 1 h; (c) HATU, NMM, r.t.; (d) 4M HCl in dioxane.
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