Scheme 2.
The synthesis of benzyl analogs.
Reagents and conditions: (a) K2CO3, acetone, reflux, 5 h; (b) NaOH, THF/EtOH/H2O=2/2/1, reflux, 1 h; (c) HATU, NMM, r.t.; (d) amine, Et3N, DCM, r.t. overnight; (e) 4M HCl in dioxane.
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