Table 2.

BACE-1 inhibitory activities of compounds 22–28.

Comp.	R2	Inhibition % (100 µM)	IC50 (µM)
19		100	1.010 ± 0.091
22		108.7	0.106 ± 0.013
23		100	0.079 ± 0.008
24		99.5	0.057 ± 0.004
25		100	0.044 ± 0.005
26		100	0.450 ± 0.058
27		103.2	0.224 ± 0.033
28		100	0.840 ± 0.101