Scheme 3.
Synthesis of unsubstituted 2-phenylpyrimidinyl ester 4c.
Reagents and conditions: (a) benzamidine hydrochloride, Na/EtOH, rt, 9 h, 50%; (b) POCl3, 100 °C, 1 h, 98%; (c) Zn, AcOH, THF, 60 °C, 23 h, 50%.
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