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Strategy for the modular synthesis of macrocyclic organo-peptide hybrids 5. The starting linear polypeptides comprise an N-terminal tail (orange), O-propargyl tyrosine, a target sequence (green), and a GyrA intein segment (light blue). Macrocyclization occurs upon coupling of this protein to a synthetic precursor (purple) by concomitant CuAAC and thioester-hydrazide coupling [31].
