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. 2013 Jul 31;18(8):9147–9162. doi: 10.3390/molecules18089147

Scheme 1.

Solid-phase synthesis of CA-PNA dimers. B1= guanine and B2= adenine in 1; B1= adenine and B2 = guanine in 2; B1 = guanine and B2 = cytosine in 3 B1 = cytosine and B2 = guanine in 4; B1 = guanine and B2 = thymine in 5; B1 = thymine and B2 = guanine in 6; B1 and B2 = guanine in 7.

Scheme 1

Reagents and conditions: i, ii 0.2 M HATU in DMF, 0.8 M monomer in base solution (Applied Biosystems) 1 h at R.T.; iii CA (2 equiv.), HOBT(2 equiv.), PyBOP (2 equiv.) and DIEA (4 equiv.) in dry DMF, over night at R.T.; iv TFA/m-cresol (4:1, v:v), 2 h.