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. 2013 Apr 10;18(4):4209–4220. doi: 10.3390/molecules18044209

Figure 1.

Figure 1

(A) Time course of hyperalgesia observed following local administration of carrageenan (250 µg/paw, i.pl.) in rats. Each point represents the mean ± S.E.M. (n = 6). *** p < 0.001 when compared to naive (vehicle alone) group (two-way ANOVA followed by Bonferroni post hoc test). (B) The effect of FKB (150, 250, 375 and 500 µg/paw, i.pl.) or ASA (500 µg/paw, i.pl.) on the nociceptive threshold in carrageenan-induced hyperalgesia in rats. FKB and ASA were administered 2 h 45 min following local administration of carrageenan (250 µg/paw, i.pl.). Each column represents the mean ± S.E.M. (n = 6). *** p < 0.001 when compared to control (C) group, ### p < 0.001 when compared to naive group. (One-way ANOVA followed by Dunnett’s post hoc test).