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The effect of pre-treatment of animals with l-arginine (25 µg/paw, i.pl.), NG-nitro-l-arginine (l-NOARG; 35 μg/paw, i.pl.) or ODQ (50 μg/paw, i.pl.) on the peripheral antinociceptive effect of FKB (500 µg/paw) against carrageenan-induced hyperalgesia test in rats. Each column represents the mean ± S.E.M. (n = 6). *** p < 0.001 when compared with control group; ## p < 0.01 when compared with l-NOARG-treated or FKB-treated group (One-way ANOVA followed by Dunnett’s post hoc test).
