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. 2013 Apr 10;18(4):4209–4220. doi: 10.3390/molecules18044209

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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The effect of intraplantar administration of K⁺ channel blockers on the peripheral antinociceptive effect of FKB against carrageenan-induced hyperalgesia test in rats. Tetraethylammonium (TEA; 200 µg/paw), glibenclamide (GLI; 200 µg/paw), charybdotoxin (ChTX; 3 µg/paw) and apamin (APA; 3 µg/paw) were administered 15 min before FKB (500 µg/paw). Each column represents the mean ± S.E.M. (n = 6). *** p < 0.001 when compared with the control (C) group; ^## p < 0.01, ^### p < 0.001 when compared with the FKB group (one-way ANOVA followed by Dunnett’s post hoc).