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. 2013 Jan 8;18(1):757–767. doi: 10.3390/molecules18010757

Figure 3.

Figure 3

Aconitine inhibited cell proliferation and induced apoptosis by modulating AKT and ERK1/2 signaling pathway. (A) Western blotting analysis of effect of aconitine on activation of AKT and ERK1/2, protein expression of PCNA and Caspase-3. β-Tubulin was used as internal control. (B, C) Analysis of kinase activities of Caspase-3 (B) or Caspase-8 (C) when B16 were treated with aconitine at 6.25 µg/mL and 12.5 µg/mL, respectively. Those B16 cells not treated with aconitine were used as control. Data were means ± SEM from three separate experiments. * p < 0.05 represented that B16 cells treated with 6.25 µg/mL of aconitine compared to control (0 µg/mL of aconitine), while # p < 0.05 represented that B16 cells treated with 12.5 µg/mL of aconitine compared to control.