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Synthesis of 1,2,4-triazoles with a N-methyl-5-indolyl moiety: tubulin inhibitor.
Reagents and conditions: (a) (i) NaH, DMF, 0 °C; (ii) CH3I (b) i-PrMgCl, −10 °C; (c) 3,4,5-(CH3O)3C6H2NCS, −10 °C to rt; (d) NH2NH2, 0 °C to rt; (e) (CH3O)3CH, H2SO4(cat.), rt.
