Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
N-Hydroxycinnamamide-based histone deacetylase inhibitors.
Reagent and conditions: (a) SOCI2, CH3OH, 98%. (b) (Boc)2O, Et3N, DCM, 80%. (c) LiAIH4, anhydrous THF, 0 °C, 86%. (d) PPh3, DEAD, anhydrous THF, 0 °C, 75% for 8a, 79% for 8b. (e) NH2OK, CH3OH, 51% for 9a, 49% for 9b. (f) HCI, anhydrous EtOAc, 90%. (g) (i) TFA, Et3N, DCM; (ii) R'COOH, TBTU, Et3N, THF, 52–75% for two steps. (h) (i) TFA, Et3N, DCM; (ii) R'SO2CI, Et3N, DCM, 60–76% for two steps. (i) NH2OK, CH3OH, 31–54%.
