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Synthesis of functionalized indoles.
Reagents and conditions: (i) 7% NaNO2, EtOH, conc. HCl, 0 °C; (ii) ethyl 2-benzyl-3-oxo-butanoate, KOH, EtOH, 0 °C; (iii) conc. HCl, reflux, 4 h; (iv) H2NNH2.H2O, EtOH, reflux, 6h; (v) 4-(non)substituted cyclohexanone, abs. EtOH, reflux, 5–6 h; (vi) mercaptoacetic acid/2-mercaptopropionic acid, dry benzene, reflux, 5–6 h; (vii) 4-(non)substituted cyclohexanone, mercaptoacetic acid/ 2-mercaptopropionic acid, dry benzene, reflux, 5–6 h.
