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2- and 3-Arylindoles.
Reagents and Conditions: (A)(i) iPrMgCl, (iPr)2NH, THF, I2, X = H, 79%, X = OMe, 89%; (ii) 10% Pd(PPh3)4, DME/EtOH, aq Na2CO3, Aryl boronic acid, reflux; (iii) K2CO3, MeOH; (iv) (a) iPrMgCl, (iPr)2NH, THF; (b) 5% Pd(PPh3)4, 2 equiv 1,4-dibromo-2,5-dimethoxybenzene. (B) (i) 10% Pd(PPh3)4, DME/EtOH, aq Na2CO3, aryl boronic acid, reflux; (ii) K2CO3, MeOH.
