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Quantitative analysis of the thiazacridine and imidazacridine derivatives effects on the relaxation of pUC19 DNA plasmid by human topoisomerase 1.
Lane 1, DNA pUC19 and lane 2, topo 1 + DNA pUC19 (controls). Lanes 3–6, topo 1 + DNA pUC19 + compounds 4–7 (50 µM), respectively; lanes 7–10, topo 1 + DNA pUC19 + compounds 4–7 (100 µM), respectively, and lanes 11–14, topo 1 + DNA pUC19 + compounds 4– 7 (200 µM), respectively.
